Trombofilia, Medycyna, Interna, Hematologia

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Thrombophilia
Michaÿ
Taszner
Michaÿ
Taszner
Department of
Hematology
Department of
and Transplantology
Medical University of Gdansk
Hematology
and Transplantology
Medical University of Gdansk
 Thrombophilia Ï
Definition
Definition I
Thrombophilia
Inherited or acquired predisposition
to form
to form
Inherited or acquired predisposition
¡
clots inappropriately -
hypercoaguable state
hypercoaguable state
clots inappropriately
(
rather
rather
venous thrombosis
venous thrombosis
,
,
seldom
seldom
artery
artery
thrombosis)
thrombosis
Laboratory abnormalities (
coagulation
coagulation
panel)
panel)
Laboratory abnormalities
¡
 Thrombophilia Ï
Definition
Definition
II
II
Thrombophilia
Predisposition to form clots arises from
interplay of acquired and genetic risk factors
¡
Predisposition to form clots arises from
interplay of acquired and genetic risk factors
50%
of
nts
with inherited thrombophilias occur in relation
of
thromboembolic episodes in
thromboembolic episodes in
pati
patie
nts
¡
50%
with inherited thrombophilias occur in relation
to events that are generally recognized
to events that are generally recognized
as a
as a
predisposing states, such
as
as
surgery, pregnancy,
surgery, pregnancy,
predisposing states, such
and immobilization
 Thrombophilia Ï
pathophysiology
pathophysiology I
Thrombophilia
Rudolf
VirchowÔs
VirchowÔs
triad (1856)
triad (1856)
Rudolf
Disorder of blood vessel wall
¡
Disorder of blood vessel wall
Disordered blood flow (stasis)
¡
Disordered blood flow (stasis)
Vessel
wall
wall
Vessel
Abnormality of blood
¡
Abnormality of blood
constituents
Thrombosis
Blood
flow
Blood
flow
Blood
elements
Blood
elements
 Thrombophilia Ï
pathophysiology
pathophysiology
II
II
Thrombophilia
Hemostatic balance between:
Fibrin formation (h
emostatic pathways)
emostatic pathways)
¡
Fibrin formation (
Fibrin dissolution (fibrinolytic pathways) +
clotting inhibitors
¡
Fibrin dissolution (fibrinolytic pathways) +
clotting inhibitors
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